A cryptic pocket in CB1 drives peripheral and functional selectivity

Rangari VA, O’Brien ES, Powers AS, Slivicki RA, Bertels Z, Appourchaux K, Aydin D, Ramos-Gonzalez N, Mwirigi J, Lin L, Mangutov E, Sobecks BL, Awad-Agbaria Y, Uphade MB, Aguilar J, Peddada TN, Shiimura Y, Huang XP, Folarin-Hines J, Payne M, Kalathil A, Varga BR, Kobilka BK, Pradhan AA, Cameron MD, Krishna Kumar K ✉︎, Dror RO ✉︎, Gereau RW 4th ✉︎, Majumdar S ✉︎.

✉︎ Co-Corresponding

Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects

Tummino TA, Iliopoulos-Tsoutsouvas C, Braz JM, O’Brien ES, Stein RM, Craik V, Tran NK, Ganapathy S, Liu F, Shiimura Y, Tong F, Ho TC, Radchenko DS, Moroz YS, Rosado SR, Bhardwaj K, Benitez J, Liu Y, Kandasamy H, Normand C, Semache M, Sabbagh L, Glenn I, Irwin JJ, Krishna Kumar K ✉︎, Makriyannis A ✉︎, Basbaum AI ✉︎, Shoichet BK ✉︎.

✉︎ Co-Corresponding

Stepwise activation of a metabotropic glutamate receptor

Krishna Kumar K ✉︎, Wang H, Habrian C, Latorraca NR, Xu J, O’Brien ES, Zhang C, Montabana E, Koehl A, Marqusee S, Isacoff EY, Kobilka BK ✉︎.

✉︎ Co-Corresponding

Structural basis for activation of CB1 by an endocannabinoid analog

Krishna Kumar K, Robertson MJ, Thadhani E, Wang H, Suomivuori CM, Powers AS, Ji L, Nikas SP, Dror RO, Inoue A, Makriyannis A, Skiniotis G, Kobilka B.

Negative allosteric modulation of the glucagon receptor by RAMP2

Krishna Kumar K, O’Brien ES, Habrian CH, Latorraca NR, Wang H, Tuneew I, Montabana E, Marqusee S, Hilger D, Isacoff EY, Mathiesen JM, Kobilka BK.

Structural insights into differences in G protein activation by family A and family B GPCRs

Hilger D*, Krishna Kumar K*, Hu H, Pedersen MF, O’Brien ES, Giehm L, Jennings C, Eskici G, Inoue A, Lerch M, Mathiesen JM, Skiniotis G, Kobilka BK.

* Co-First Author

Structure of a signaling cannabinoid receptor 1–G protein complex

Krishna Kumar K, Shalev-Benami M, Robertson MJ, Hu H, Banister SD, Hollingsworth SA, Latorraca NR, Kato HE, Hilger D, Maeda S, Weis WI, Farrens DL, Dror RO, Malhotra SV, Kobilka BK, Skiniotis G.

A cryptic pocket in CB1 drives peripheral and functional selectivity

Rangari VA, O’Brien ES, Powers AS, Slivicki RA, Bertels Z, Appourchaux K, Aydin D, Ramos-Gonzalez N, Mwirigi J, Lin L, Mangutov E, Sobecks BL, Awad-Agbaria Y, Uphade MB, Aguilar J, Peddada TN, Shiimura Y, Huang XP, Folarin-Hines J, Payne M, Kalathil A, Varga BR, Kobilka BK, Pradhan AA, Cameron MD, Krishna Kumar K ✉︎, Dror RO ✉︎, Gereau RW 4th ✉︎, Majumdar S ✉︎.

✉︎ Co-Corresponding

Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects

Tummino TA, Iliopoulos-Tsoutsouvas C, Braz JM, O’Brien ES, Stein RM, Craik V, Tran NK, Ganapathy S, Liu F, Shiimura Y, Tong F, Ho TC, Radchenko DS, Moroz YS, Rosado SR, Bhardwaj K, Benitez J, Liu Y, Kandasamy H, Normand C, Semache M, Sabbagh L, Glenn I, Irwin JJ, Krishna Kumar K ✉︎, Makriyannis A ✉︎, Basbaum AI ✉︎, Shoichet BK ✉︎.

✉︎ Co-Corresponding

Stepwise activation of a metabotropic glutamate receptor

Krishna Kumar K ✉︎, Wang H, Habrian C, Latorraca NR, Xu J, O’Brien ES, Zhang C, Montabana E, Koehl A, Marqusee S, Isacoff EY, Kobilka BK ✉︎.

✉︎ Co-Corresponding

A µ-opioid receptor modulator that works cooperatively with naloxone

O’Brien ES, Rangari VA, El Daibani A, Eans SO, Hammond HR, White E, Wang H, Shiimura Y, Krishna Kumar K, Jiang Q, Appourchaux K, Huang W, Zhang C, Kennedy BJ, Mathiesen JM, Che T, McLaughlin JP, Majumdar S, Kobilka BK.

Structural basis for activation of CB1 by an endocannabinoid analog

Krishna Kumar K, Robertson MJ, Thadhani E, Wang H, Suomivuori CM, Powers AS, Ji L, Nikas SP, Dror RO, Inoue A, Makriyannis A, Skiniotis G, Kobilka B.

The ubiquitination status of the glucagon receptor determines signal bias

Kaur S, Sokrat B, Capozzi ME, El K, Bai Y, Jazic A, Han B, Krishna Kumar K, D’Alessio DA, Campbell JE, Bouvier M, Shenoy SK.

Negative allosteric modulation of the glucagon receptor by RAMP2

Krishna Kumar K, O’Brien ES, Habrian CH, Latorraca NR, Wang H, Tuneew I, Montabana E, Marqusee S, Hilger D, Isacoff EY, Mathiesen JM, Kobilka BK.

Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation

Wei TT, Chandy M, Nishiga M, Zhang A, Krishna Kumar K, Thomas D, Manhas A, Rhee S, Justesen JM, Chen IY, Wo HT, Khanamiri S, Yang JY, Seidl FJ, Burns NZ, Liu C, Sayed N, Shie JJ, Yeh CF, Yang KC, Lau E, Lynch KL, Rivas M, Kobilka BK, Wu JC.

Structural insights into differences in G protein activation by family A and family B GPCRs

Hilger D*, Krishna Kumar K*, Hu H, Pedersen MF, O’Brien ES, Giehm L, Jennings C, Eskici G, Inoue A, Lerch M, Mathiesen JM, Skiniotis G, Kobilka BK.

* Co-First Author

Viewing rare conformations of the β2 adrenergic receptor with pressure-resolved DEER spectroscopy

Lerch MT, Matt RA, Masureel M, Elgeti M, Krishna Kumar K, Hilger D, Foys B, Kobilka BK, Hubbell WL.

Conformational transitions of a neurotensin receptor 1-G(i1) complex

Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G.

Structure of a signaling cannabinoid receptor 1–G protein complex

Krishna Kumar K, Shalev-Benami M, Robertson MJ, Hu H, Banister SD, Hollingsworth SA, Latorraca NR, Kato HE, Hilger D, Maeda S, Weis WI, Farrens DL, Dror RO, Malhotra SV, Kobilka BK, Skiniotis G.

Selective modulation of the cannabinoid type 1 (CB1) receptor as an emerging platform for the treatment of neuropathic pain

Banister SD, Krishna Kumar K, Kumar V, Kobilka BK, Malhotra SV.

Self-assembly behaviors of a penta-phenylene maltoside and its application for membrane protein study

Ehsan M, Kumar A, Mortensen JS, Du Y, Hariharan P, Krishna Kumar K, Ha B, Byrne B, Guan L, Kobilka BK, Loland CJ, Chae PS.

Asymmetric maltose neopentyl glycol amphiphiles for a membrane protein study: effect of detergent asymmetricity on protein stability.

Bae HE, Du Y, Hariharan P, Mortensen JS, Krishna Kumar K, Ha B, Das M, Lee HS, Loland CJ, Guan L, Kobilka BK, Chae PS.

Crystal structure of Bax bound to the BH3 peptide of Bim

Robin AY, Krishna Kumar K, Westphal D, Wardak AZ, Thompson GV, Dewson G, Colman PM, Czabotar PE.

The structure of α-haemoglobin in complex with a haemoglobin-binding domain from Staphylococcus aureus reveals the elusive α-haemoglobin dimerization interface

Krishna Kumar K, Jacques DA, Guss JM, Gell DA.

Structure and function of LGR5: an enigmatic G-protein coupled receptor marking stem cells

Krishna Kumar K, Burgess AW, Gulbis JM.

The role of proteases and inflammatory molecules in triggering neovascular age-related macular degeneration: basic science to clinical relevance

Balasubramanian SA, Krishna Kumar K, Baird PN.

Structure of the hemoglobin-IsdH complex reveals the molecular basis of iron capture by Staphylococcus aureus.

Dickson CF, Krishna Kumar K, Jacques DA, Malmirchegini GR, Spirig T, Mackay JP, Clubb RT, Guss JM, Gell DA.

Staphylococcus aureus uses a novel multidomain receptor to break apart human hemoglobin and steal its heme.

Spirig T, Malmirchegini GR, Zhang J, Robson SA, Sjodt M, Liu M, Krishna Kumar K, Dickson CF, Gell DA, Lei B, Loo JA, Clubb RT.

Structural basis for hemoglobin capture by Staphylococcus aureus cell-surface protein, IsdH

Krishna Kumar K, Jacques DA, Pishchany G, Caradoc-Davies T, Spirig T, Malmirchegini GR, Langley DB, Dickson CF, Mackay JP, Clubb RT, Skaar EP, Guss JM, Gell DA.

AHSP (α-haemoglobin-stabilizing protein) stabilizes apo-α-haemoglobin in a partially folded state

Krishna Kumar K, Dickson CF, Weiss MJ, Mackay JP, Gell DA.

Hybridoma generation by in vitro immunization of murine splenocytes with cytosolic proteins of Chinese hamster ovary (CHO) mitotic cells

Ravi M, Sundar SS, Krishna Kumar K, Parvathi D, Paul SF.