01

Decoding Signaling Specificity

Cells encounter many extracellular signals, but how do receptors convert them into distinct cellular outcomes? We investigate how receptor composition, assembly, and engagement of downstream effectors encode signaling specificity and determine cell fate.

02

Receptor Activation Dynamics

Receptors are dynamic proteins that sample multiple conformational states. We investigate how ligands and signaling partners reshape these energy landscapes to stabilize distinct receptor states and control activation, efficacy, and signaling bias.

03

Engineering Receptor Signaling

We use mechanistic insights into receptor activation and signaling to engineer new ways to control receptor function. Our goal is to develop molecules that selectively stabilize specific receptor states and reprogram downstream signaling pathways.

04

Signaling Across Evolution

Cellular signaling has evolved diverse solutions to the same fundamental challenge: sensing and responding to the environment. By studying receptor systems across organisms, we aim to uncover unexpected signaling mechanisms and identify conserved principles that govern cellular communication.